![]() COS-7 cells coexpressing LHRd and LHRa also failed to generate cAMP in response to LH, suggesting that this truncated form has a negative effect on the signaling of LHRa. COS-7 cells expressing LHRd were unable to produce cAMP in response to LH stimulation. LHRd encodes a protein lacking the transmembrane and carboxyl terminal domains. ![]() Chronic manipulation of human chorionic gonadotropin in LGC primary cultures supported the in vivo findings. Conversely, an increase in LHRd expression was observed in the late luteal CL ( P < 0.01). ![]() LHRa expression was reduced in the late luteal CL ( P < 0.05). Real-time quantitative PCR revealed that expression of the full-length LHR (LHRa) and the most truncated form (LHRd) changed significantly in CL harvested at different stages of the ovarian cycle ( P < 0.01, ANOVA). ![]() We previously identified four splice variants of the LHR in human luteinized granulosa cells (LGCs) and corpora lutea (CL). The human LH receptor (LHR) plays a key role in luteal function and the establishment of pregnancy through its interaction with the gonadotropins LH and human chorionic gonadotropin.
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